2013年国际抗癫痫总会抗癫痫药使用指南
2022-04-21 00:34:55 来源: 衡阳癫痫医院 咨询医生
he purpose of this report was to update the 2006 International League Against Epilepsy (ILAE) report and identify the level of evidence for long-term efficacy or effectiveness for antiepileptic drugs (AEDs) as initial monotherapy for patients with newly diagnosed or untreated epilepsy. All applicable articles from July 2005 until March 2012 were identified, evaluated, and combined with the previous ysis (Glauser et al., 2006) to provide a comprehensive update.
The prior ysis methodology was utilized with three modifications: (1) the detectable noninferiority boundary approach was dropped and both failed superiority studies and prespecified noninferiority studies were yzed using a noninferiority approach, (2) the definition of an adequate comparator was clarified and now includes an absolute minimum point estimate for efficacy/effectiveness, and (3) the relationship table between clinical trial ratings, level of evidence, and conclusions no longer includes a recommendation column to reinforce that this review of efficacy/evidence for specific seizure types does not imply treatment recommendations.
This evidence review contains one clarification: The commission has determined that class I superiority studies can be designed to detect up to a 20% absolute (rather than relative) difference in the point estimate of efficacy/effectiveness between study treatment and comparator using an intent-to-treat ysis. Since July, 2005, three class I randomized controlled trials (RCT) and 11 class III RCTs he been published. The combined ysis (1940-2012) now includes a total of 64 RCTs (7 with class I evidence, 2 with class II evidence) and 11 meta-yses.
New efficacy/effectiveness findings include the following: levetiracetam and zonisamide he level A evidence in s with partial onset seizures and both ethosuximide and valproic acid he level A evidence in children with childhood absence epilepsy.
There are no major changes in the level of evidence for any other subgroup. Levetiracetam and zonisamide join carbamazepine and phenytoin with level A efficacy/effectiveness evidence as initial monotherapy for s with partial onset seizures. Although ethosuximide and valproic acid now he level A efficacy/effectiveness evidence as initial monotherapy for children with absence seizures, there continues to be an alarming lack of well designed, properly conducted epilepsy RCTs for patients with generalized seizures/epilepsies and in children in general.
These findings reinforce the need for multicenter, multinational efforts to design, conduct, and yze future clinically relevant adequately designed RCTs. When selecting a patient's AED, all relevant variables and not just efficacy and effectiveness should be considered.
查看信源地址
下一页:全面性癫痫的后遗症研究
- 2022-04-212013年国际抗癫痫总会抗癫痫药使用指南
- 2022-04-04著名女演员愤怒地告诉莆田妇科医院 要求在全国媒体上公开道歉
- 2022-03-09为什么光疗能有效治疗白癜风?
- 感觉肿块,增生还是癌症?
- 今夜就出发,致敬这群“逆行者”!
- 手掌侧钢板内固定带蒂骨移植治疗舟骨
- 治疗类风湿性关节炎/膝骨关节炎的专家共识
- 疾病新知:毛囊性白癜风
- 女性涂精油保养,竟然长出24斤!
- 著名女演员愤怒地告诉莆田妇科医院 要求在全国媒体上公开道歉
- 第一次同房失败,怎么治疗?
- 副作用越多越好
- 铠侠对生命科学研究成果中的大容量数据进行加速分析
- 头骨畸形怎么办?
- Stroke:家族性和散发性颅内动脉瘤破裂的风险比较
- 非淋性尿道炎症状 非淋性尿道炎怎么办?
- 【预约直播】铿锵的论道 不炎,越来越多--「郁金香论坛」学术沙龙即将举行
- Alz Res Therapy:健康饮食可以降低痴呆的风险
- 第二届微创、超声介入学科发展及临床应用研讨会
- 精彩幻灯:一网打尽妇科常见病
- 内陷困扰及治疗方案
- CSP2016:李凌江教授谈论了与应激创伤障碍相关的问题
- 子宫内膜异位症和子宫腺肌病有什么区别?
- 注意┃要好好照顾,不仅可以避免妇科疾病,还有助于怀孕!
- NICE推荐将Elmiron(戊糖多钠)治疗膀胱疼痛综合征
- BJOG:口服补充剂对孕期微生物群的影响
- 为什么光疗能有效治疗白癜风?
- BMJ:血浆置换对ANCA相关性血管炎患者的影响
- 女生有妇科炎症,能自愈吗?
- 癫痫病怎样治果会好
- 癫痫病的征状及治疗
- 新版医保药品多达2800种 “逢进必谈”的药都有哪些?一起来看!
- 癫痫病的发病环境因素主要有哪些
- 羊癫疯高烧的症状体征
- 孩童得了癫痫病有什么症状
- 什么是难治性癫痫?切除办法及适应症
- 癫痫病的心脏病病因有哪些
- 类似于的癫痫病发作的症状有哪些
- 癫痫病的诊断要了解什么病因
- 中科东北部干细胞研究院:干细胞治疗脑出血后遗症国内有新药了!
- 新生儿癫痫病怎么疗法
- 怎么治疗癫痫病视觉效果比较好
- Radiology:利用MR指纹识别评价后侧颞叶癫痫病灶的价值